Aedes aegypti is the primary disease vector for both Dengue and Yellow Fever. Climate change is affecting the natural environment of these mosquitoes, yet the extent to which individuals and populations can physiologically respond to environmental stressors is unknown. Understanding the mechanics of A. aegypti stress responses has important implications for predicting both mosquito and disease distribution patterns in the context of a rapidly changing global environment. In this research, the genetic response of adult female A. aegypti mosquitoes to dehydration stress is investigated using quantitative PCR. Homologs of four physiologically relevant genes (Frost, Desat2, HSP70 and Pepck) are examined in A. aegypti. Mosquitoes were subjected to acute desiccation stress and then analyzed via qPCR to determine the extent to which these genes' expression patterns were altered. Altered gene expression in response to desiccation stress was observed for HSP 70, while evidence suggesting the evolutionary divergence of Frost was also uncovered. These results provide clues as to which physiological mechanisms are utilized by A. aegypti to mediate survival in desiccating environments. Genetic indicators of these mechanisms can be used in comparative studies against geographically distinct populations to generate an understanding of stress resistance mechanisms in A. aegypti as a function of geography and environment.