000004511 001__ 4511 000004511 005__ 20230910122642.0 000004511 037__ $$aTHESIS 000004511 041__ $$aeng 000004511 245__ $$aA Mathematical Exploration of Strategies to Combat and Control the Zika Virus 000004511 260__ $$c4/17/20 000004511 270__ $$ml_stierman@coloradocollege.edu 000004511 300__ $$a38 000004511 300__ $$bIllustrations and/or graphics, maps 000004511 336__ $$atext 000004511 380__ $$aThesis 000004511 502__ $$d2020 000004511 502__ $$nMathematics and Computer Science Department 000004511 520__ $$aThe Zika Virus (ZIKV) -- transmitted both vectorially by mosquitoes and sexually among humans -- causes short-term and non-lethal infections but also induces acute complications during pregnancy, such as microcephaly. In this paper, we employ an epidemiological model of both modes of transmission in order to assess key strategic efforts to prevent the spread of infection. We consider self-protection from mosquito bites, depletion of mosquito populations, and control of sexual transmission; evaluating their respective effects on the spread of Zika Virus infections. We also propose two extensions of this model which incorporate live and passive vaccination. Using these models, we investigate the influence of such immunization strategies, specifically examining the significance of vaccination in relation to the time at which an outbreak commences. For each strategy, we evaluate its practicality and its capacity to limit or decelerate transmission of ZIKV. 000004511 542__ $$fCopyright reserved, non-exclusive rights granted to Colorado College for distribution. 000004511 650_4 $$aZika Virus 000004511 650_4 $$aZIKV 000004511 650_4 $$aEpidemiology 000004511 650_4 $$aMathematical Model 000004511 650_4 $$aInfectious Disease 000004511 650_4 $$aVaccination 000004511 7001_ $$aStierman, Lauren Marie 000004511 72012 $$aBruder, Andrea 000004511 980__ $$aIR 000004511 982__ $$aMathematics and Computer Science Department Student Theses 2019-20