The Zika Virus (ZIKV) -- transmitted both vectorially by mosquitoes and sexually among humans -- causes short-term and non-lethal infections but also induces acute complications during pregnancy, such as microcephaly. In this paper, we employ an epidemiological model of both modes of transmission in order to assess key strategic efforts to prevent the spread of infection. We consider self-protection from mosquito bites, depletion of mosquito populations, and control of sexual transmission; evaluating their respective effects on the spread of Zika Virus infections. We also propose two extensions of this model which incorporate live and passive vaccination. Using these models, we investigate the influence of such immunization strategies, specifically examining the significance of vaccination in relation to the time at which an outbreak commences. For each strategy, we evaluate its practicality and its capacity to limit or decelerate transmission of ZIKV.