Over the past few decades, the United States has been suffering from a nursing shortage and increasing job dissatisfaction and burnout of the healthcare workforce. This study analyzes a series of personal and workplace variables of registered nurses versus job satisfaction. The effect of these variables on job satisfaction is measured using survey data from 2013, 2015, and 2016. Using an ordinary least squares (OLS) regression, it was found that strain injuries, marital status, personal health status, and willingness to take the same job again are strongly correlated to job satisfaction.