Alzheimer Disease (AD) is the most common form of neurodegeneration in humans, currently affecting over 6 million Americans. In this study, we examined circular RNAs (circRNAs) of two AD-related genes, presenilin 1 (PSEN1) and presenilin 2 (PSEN2), for the presence of pathogenic variants. Previous research suggests that circRNA are heavily implicated in neuronal gene regulation; however, their precise role in AD pathogenesis has yet to be established. cDNA from individuals with pathogenic variants in these genes was PCR amplified using divergent primers to target back-spliced regions specific to circRNAs, and the purified PCR product was subsequently Sanger sequenced. Four variants, I143T, S212Y, M146L in PSEN1, and N141I in PSEN2, were identified in circRNAs. The presence of pathogenic variation in circRNAs marks a crucial first step in determining their role in AD pathogenesis. To our knowledge, this research is the first of its kind to identify pathogenic variants in circRNAs of AD risk genes.