The integration of subjects/domains in the classroom is key to student engagement and to developing the critical thinking skills which allow children to make connections and globalize thinking. Neuroscience has given new insight into how the amygdala and the reticular activating system (RAS) filter data, providing understanding to why integration works. In order for the brain to process information globally and make connections, relevancy and context are critical. When students learn subjects departmentally without real world applications, the brain often fails to make connections to other subjects or situations and causes students to become disengaged from the learning. Integrating social studies with math, literacy and science skills and concepts through Culturally Responsive Teaching (CRT) practices enables students to develop understanding and appreciation for their world, while still teaching math and literacy skills and science concepts; the main focus of today’s education. This research explored the validity and value of integrating subjects. The results showed that the integration of two or more subjects did increase engagement and generate deeper understanding.