Although meat consumption contributes to climate change, animal suffering, antibiotic resistance, and several other problems, large segments of the population are unwilling to change their eating habits. Cell-based meat has been proposed as a potential solution to replace meat without sacrificing taste. Despite the potential benefits of this alternative, many questions remain about consumer acceptance. The present study investigated how individual differences and motivations for eating/avoiding meat affect participants’ likelihood of trying cell-based meat. Additionally, the description of the product was manipulated to explore if matching the framing to the consumer’s motivation increased likelihood. Participants took an approximately 6-minute survey that asked about food motivations, likelihood of trying cell-based meat, and measured individual differences. Motivation matching did not significantly increase the likelihood of trying cell-based meat. Most of the individual differences were not significantly related, but men and those higher in masculinity were more likely to try the product. Because this demographic is resistant to other meat substitutes, cell-based meat could provide an alternative for certain groups of people that would otherwise consume traditional meat. Food decisions are difficult to change, so it is possible that these descriptions were not enough to demonstrate significant effects. Further research should devise stronger manipulations for effective advertising surrounding cell-based meat.